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Madonna
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During her concert at the Ziggo Dome in Amsterdam, Netherlands, Madonna shared with fans about a heart-crushing moment when she held a friend's hand as he died from AIDS.

She delivered her powerful speech on December 1, which was World AIDS Day, designated since 1988 to raise awareness of AIDS and in remembrance of those who've died of the disease caused by the spread of HIV (human immunodeficiency virus) infection.

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