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He said he separated himself from his family out of caution by sleeping in a different part of the house and felt feverish throughout the night.
"And I knew what was going on," said the 54-year-old.
When Rogan got tested the following morning, the result came back positive for the virus.
He proceeded to list his combating measures against the virus that included immediately throwing the "kitchen sink" at it.
Rogan said he used monoclonal antibodies, ivermectin, Z-Pak, and prednisone.
He also took a NAD drip and a vitamin D drip for three days in a row.
"And here we are on Wednesday, and I feel great. I really only had one bad day — Sunday sucked."
One of the medications he took, ivermectin, was met with controversy online.
In veterinary medicine, ivermectin is an anti-parasite drug used for livestock deworming.
Although the drug is approved by the Food and Drug Administration (FDA), the agency does not approve or authorize ivermectin for treating or preventing infection from the viral pathogen responsible for the current health crisis, according to their website.
"There's a lot of misinformation around, and you may have heard that it's okay to take large doses of ivermectin. That is wrong," said the agency.
"For one thing, animal drugs are often highly concentrated because they are used for large animals like horses and cows, which can weigh a lot more than we do—a ton or more. Such high doses can be highly toxic in humans."
In response to the widespread misinformation and increasing phone calls to poison control centers from Americans who have injected ivermectin, the FDA tweeted last month:
"You are not a horse. You are not a cow. Seriously, y'all. Stop it."
@US_FDA/Twitter
It is unclear whether or not Rogan was vaccinated, but he did say he was planning on getting the Johnson & Johnson vaccine before it was paused.
Rogan previously suggested on his podcast that young and healthy people don't need to get vaccinated.
He said:
"If you're like 21 years old and you say to me, 'Should I get vaccinated?' I'll go, 'No.' If you're a healthy person and you're exercising all the time and you're young and you're eating well, I don't think you need to worry about this."
@NumbersMuncher/Twitter
People had plenty to say about the outspoken comedian and his remedy choice.
"Today I feel good," said Rogan of his current status in the clip. "I actually feel pretty f'king good."
He apologized to fans for postponing his show at Bridgestone Arena in Nashville to October 24, adding, "Obviously this is nothing I can control."
In conclusion, he offered "a wonderful, heartfelt thank you to modern medicine for pulling me out of this so quickly and easily."